PROHIP Quality
PRO HIP Quality studiet undersøger om én dosis antibiotika er ligeværdig med multiple doser det første
postoperative døgn ved primær THA. Alle danske ortopædkirurgiske afdelinger, både offentlige og private,
deltager i projektet, hvilket gør det til det første komplette nationale ortopædkirurgiske studie. Inklusion
af patienter startede i september 2022, og pr. 1. december 2022 var alle afdelinger i gang. Status fra
afdelingerne er, at projektet kører efter planen. I efteråret 2023 vil der ske en overkrydsning, og
afdelingerne vil skifte standardinstrukser for antibiotikaprofylakse. Resultaterne fra projektet vil blive
præsenteret i 2025.

PhD afhandlinger
2023 Rasmus Tyrsted Mikkelsen. Bearings in hip arthroplasty – Diagnostics and prognosis of adverse reaction to metal debris and long-term risk ofrevision in young patients. University of Southern Denmark.

2021 Nina McKinnon Edwards. The Impact of Socioeconomic status on Total Hip Arthroplasty – Utilization and postoperative complications. Aarhus University

2021 Astrid Blicher Schelde. Anticoagulant therapy in patients undergoing elective total hip or knee replacement
University of Copenhagen

2020 Lars Lykke Hermansen. Hip dislocation after primary Total Hip Arthroplasty –Incidence & patient reported outcome. University of Southern Denmark

2020 Kristian Kjærgaard. Measuring longevity of total hip replacements with vitamin E-doped liner. University of Southern Denmark

2019 Alexander Steenberg Dastrup. Tranexamic acid, non-steroidal anti-inflammatory drugs, and statins, and the risk of major cardiovascular events and death following total hip replacement surgery – A population based study from the Danish Hip Arthroplasty Register. University of Southern Denmark

2019 René L. Cordtz. Impact of treatment with biologics on the incidence, time trends and outcomes of joint replacement surgery in patients with rheumatoid arthritis University of Copenhagen

2017 Søren Glud Skousgaard. Osteoarthritis of the Hip and Knee leading to Total Joint Arthroplasty – Probability and Heritability Estimates with an examination of Occupational and Environmental Risk Factors.
University of Southern Denmark

2017 Eva Glassou Total hip and knee arthroplasty – studies on prognostic
factors for readmission, reoperation and mortality
Aarhus University

2016 Thomas Deleuran. Cirrhosis of the liver and diseases of the large joints. Faculty of Health Sciences. Aarhus University

2016 Claus Varnum. Outcome of different bearings in total hip arthroplasty – implant survival, revision causes, and patient-reported outcome. University of Southern Denmark

2016 Per Gundtoft. Prosthetic Joint Infection following Total Hip Arthroplasty – Incidence, Mortality and Validation of the Diagnosis in the Danish Hip Arthroplasty Register. University of Southern Denmark

2015 Martin Lindberg-Larsen. Early morbidity after bilateral and revision hip and knee arthroplasty. University of Copenhagen

2014 Aksel Paulsen. Patient Reported Outcomes in Hip Arthroplasty Registries University of Southern Denmark

2009 Theis Thillemann. Use of medications and risk of revision after primary total hip arthroplasty. Aarhus University

2006 Alma B. Pedersen. Studies based on the Danish Hip Arthroplasty Registry Aarhus University

Igangværende PhD–studier
1. Rajzan Roanroy. Prosthetic joint infection after total hip arthroplasty – Seasonal variation, type of
microorganisms, and resistance patterns. University of Southern Denmark.
2. Armita Armina Abedi. Use of antibiotic prophylaxis and prevention of PJI in Total Hip
Arthroplasty. University of Copenhagen.
3. Saber M. Saber. Outcomes and risk of revision following hip and knee arthroplasty in patients
with osteoarthritis and obesity. University of Copenhagen.
4. Ida Paulsen Møller. Metal-on-metal hip arthroplasty – Association between blood metal ion levels
and risk of heart disease. University of Southern Denmark.
5. Jens Holm Laigaard. Perioperative Interventions for Reduction of Persistent Pain after Total Hip
and Knee Arthroplasty. University of Copenhagen.
6. Afrim Iljazi. Hip joint stability after total hip arthroplasty – which type of artificial hip joint and
postoperative regimen should be selected for the individual patient? University of Copenhagen.
7. Andre Sejr Klenø. The impact of social, patient, and selected healthcare factors on the inequality
in opioid use and subsequent outcome among patients undergoing total hip arthroplasty. Aarhus
University.
8. Nicolai Kjældgaard Kristensen. Mortality and Causes of Death after Revision due to Periprosthetic
Joint Infection of knee and hip arthroplasty. Aarhus University.
9. Martin Bækgaard Stisen. Revision total Hip Replacement. Development and testing of an
optimised community-based rehabilitation, investigation of prognostic factors of poor outcomes
after revision total hip replacement and rates of serious adverse events post-surgery. Aarhus
University.

Doctoral Dissertation
2016
1. Alma B. Pedersen. Total hip replacement surgery – occurrence and prognosis. Aarhus University.

Artikler
Der er publiceret 104 videnskabelige artikler med data fra Dansk Hoftealloplastikregister, hvoraf de nyeste
er oplistet herunder:

89. Hermansen LL, Viberg B, Hansen L, Overgaard S. Patient-reported outcome after dislocation of
primary total hip arthroplasties: a cross-sectional study derived from the Danish Hip Arthroplasty
Register. Acta Orthop. 2022 Jan 3;93:29-36.
90. Klenø AN, Stisen MB, Edwards NM, Mechlenburg I, Pedersen AB. Socioeconomic status and use of
analgesic drugs before and after primary hip arthroplasty: a population-based cohort study of
103,209 patients during 1996-2018. Acta Orthop. 2022 Jan 3;93:171-178.
91. Lindberg-Larsen M, Petersen PB, Corap Y, Gromov K, Jørgensen CC, Kehlet H, Centre for Fast-
track Hip and Knee Replacement Collaborating Group. Fast-track revision hip arthroplasty: a
multicenter cohort study on 1,345 elective aseptic major component revision hip arthroplasties.
Acta Orthop. 2022 Feb 23;93:341-347.
92. Edwards NM, Varnum C, Nelissen RGHH, Overgaard S, Pedersen AB. The association between
socioeconomic status and the 30- and 90-day risk of infection after total hip arthroplasty: a
registry-based cohort study of 103,901 patients with osteoarthritis. Bone Joint J. 2022 Feb;104-
B(2):221-226.
93. Bülow E, Hahn U, Andersen IT, Rolfson O, Pedersen AB, Hailer NP. Prediction of Early
Periprosthetic Joint Infection After Total Hip Arthroplasty. Clin Epidemiol. 2022 Mar 4;14:239-253.
94. Henkel C, Styrkársdóttir U, Thorleifsson G, Stefánsdóttir L, Björnsdóttir G, Banasik K, Brunak S,
Erikstrup C, Dinh KM, Hansen TF, Nielsen KR, Bruun MT, Dowsett J, Brodersen T; DBDS Genomic
Consortium; Thorgeirsson TE, Gromov K, Boesen MP, Ullum H, Ostrowski SR, Pedersen OB,
Stefánsson K, Troelsen A. Genome-wide association meta-analysis of knee and hip osteoarthritis
uncovers genetic differences between patients treated with joint replacement and patients
without joint replacement. Ann Rheum Dis. 2023 Mar;82(3):384-392.
95. Benson TE, Andersen IT, Overgaard S, Fenstad AM, Lie SA, Gjertsen JE, Furnes ON, Pedersen AB.
Association of perioperative thromboprophylaxis on revision rate due to infection and aseptic
loosening in primary total hip arthroplasty – new evidence from the Nordic Arthroplasty Registry
Association (NARA). Acta Orthop. 2022 Apr 8;93:417-423.
96. Stisen MB, Klenø AN, Jacobsen JS, O’Connell MDL, Ayis S, Sackley C, Pedersen AB, Mechlenburg I.
Do changes in outcomes following primary and revision hip replacement differ and relate to
markers of socioeconomic status? A 1-year population-based cohort study. Acta Orthop. 2022
Apr 6;93:397-404.
97. Hermansen LL, Viberg B, Overgaard S. Large hospital variation in the risk of dislocation after
primary total hip arthroplasty for primary osteoarthritis: 31,105 patients in 59 hospitals from the
Danish Hip Arthroplasty Register. Acta Orthop. 2022 May 31;93:503-508.
98. Kjærgaard K, Varnum C, Ding M, Overgaard S. Revision Risk of Total Hip Arthroplasty With Vitamin
E Doped Liners: Results From the Danish Hip Arthroplasty Register. J Arthroplasty. 2022
Jun;37(6):1136-1142.
99. Farey JE, Masters J, Cuthbert AR, Iversen P, van Steenbergen LN, Prentice HA, Adie S, Sayers A,
Whitehouse MR, Paxton EW, Costa ML, Overgaard S, Rogmark C, Rolfson O, Harris IA. Do Dual-
mobility Cups Reduce Revision Risk in Femoral Neck Fractures Compared With Conventional THA
Designs? An International Meta-analysis of Arthroplasty Registries. Clin Orthop Relat Res. 2022
Oct 1;480(10):1912-1925.
100. Edwards NM, Kristensen EB, Varnum C, Overgaard S, Nelissen RGHH, Pedersen AB. The
association between socioeconomic status and the 90-day risk of cardiovascular events after
Dansk Hoftealloplastik Register – Årsrapport 2022 – Udgivet 2023 113
total hip arthroplasty – registry-based study of 103,286 patients. Acta Orthop. 2022 Nov 7;93:837-
848.
101. Rasmussen MB, El-Galaly A, Daugberg L, Nielsen PT, Jakobsen T. Projection of primary and
revision hip arthroplasty surgery in Denmark from 2020 to 2050. Acta Orthop. 2022 Nov
22;93:849-853.

102. Dale H, Fenstad AM, Hallan G, Overgaard S, Pedersen AB, Hailer NP, Kärrholm J, Rolfson O,
Eskelinen A, Mäkelä KT, Furnes O. Increasing risk of revision due to infection after primary total
hip arthroplasty: results from the Nordic Arthroplasty Register Association. Acta Orthop. 2023
Jun 27:94:307-315.
103. Mikkelsen RT, Overgaard S, Pedersen AB, Kärrholm J, Rolfson O, Fenstad AM, Furnes O, Hallan G,
Mäkelä K, Eskelinen A, Varnum C. Does choice of bearings influence the survival of cementless
total hip arthroplasty in patients aged 20-55 years? Comparison of 21,594 patients reported to
the Nordic Arthroplasty Register Association dataset 2005-2017. Acta Orthop. 2023 Jun 5:94:266-
273.
104. Lind ANR, Jakobsen SKM, Klenø AS, Pedersen AB. Sex and age differences in the use of analgesic
drugs before and after primary total hip arthroplasty in 105,520 Danish patients. Surgeon. 2023
Dec;21(6):381-389.